Ce poste de technicien d'étude clinique est à pourvoir au sein de l’unité de recherche INSERM U970 dans l’équipe 11 : Approches multidimensionnelles en transplantation d’organes dirigée par le Pr Alexandre Loupy.
Ce poste s’intègre au sein d’un projet se focalisant sur la transplantation pulmonaire. Actuellement, la prédiction du succès ou de l’échec d’une greffe pulmonaire reste difficile car les mécanismes immunologiques autour d’un greffon sont mal connus.
Notre équipe s’intéresse aux approches personnalisées pour la prédiction de risque post-transplantation (notamment les risques de survenue de rejet) par l’intégration d’informations multidimensionnelles. Cela regroupe des données provenant de la clinique, de l’histologie classique, de la biologie et éventuellement des données provenant de technologies innovantes en immunologie, biologie moléculaire, génétique et biomarqueurs.
Ce poste d'assistant de recherche clinique est à pourvoir au sein de l’unité de recherche INSERM U970 dans l’équipe 11 : Approches multidimensionnelles en transplantation d’organes dirigée par le Pr Alexandre Loupy.
Notre équipe s’intéresse aux approches personnalisées en médecine de la transplantation par l’intégration d’informations multidimensionnelles provenant de l’histologie classique, de la biologie et de la science clinique ainsi que des informations nouvelles provenant de technologies innovantes en immunologie, biologie moléculaire, génétique et biomarqueurs.
Ce poste s’intègre dans le cadre d’un nouveau projet se focalisant sur la transplantation hépatique ayant pour objectifs : de précision diagnostique et la stratification du rejet en transplantation hépatique.
His/her duties will include creating various machine learning-based tools or processes within the team, such as recommendation engines or automated lead scoring systems. The resource within this role should also be able to perform statistical analysis. You are detail-oriented, meticulous, and an analytical team player. You ask the right questions, effectively communicate across teams, and want an opportunity to help shape what data can offer to our knowledge of organ transplantation.
The topic of ATC 2020 is “The Science of Tomorrow Starts Today” and covers the latest research in the field of transplantation. It showcases the research done in the industry too.
A considerable decline in the number of organ transplants since the start of the COVID-19 pandemic in France and the US
Identification and characterization of trajectories of cardiac allograft vasculopathy after heart transplantation
One of the most common reasons for long-term graft failure and patient death is an accelerated form of coronary artery disease called cardiac allograft vasculopathy. It is a frequent complication that affects up to half of patients within 10 years following heart transplantation. Yet, until now, little has been known about the different evolutive profiles of cardiac allograft vasculopathy and their risk factors.
Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study
The members of the Paris Transplant Group are present at the SFT congress which will take place from December 3, 2019 in Bordeaux, France.
The team of the Paris Transplant Group has been awarded at the ESOT 2019 congress in Copenhagen for its many contribution in the field of transplantation.
The Prize is given to a single Institution having submitted at least 5 abstracts for the event and granted with the best score. The Paris Transplant Group is very pleased to won this European award twice in a row.
Check out the contribution submitted by the Group on the ESOT website: esotcongress.org.
Olivier Aubert is awarded for its work on "Disparities in the acceptance of deceased donor kidney and consequences for transplant access: nationwide analysis of practice in the US and France". The co-authors of this work are affiliated to Paris Translational Center for Organ Transplantation, the University of Pennsylvania, Philadelphia, US ; the Agence de la Biomédecine of France and two Parisian transplantation centres: Necker Hospital and Saint Louis Hospital.
Find more information about the study in the article published in the JAMA journal: access the full study.
Disparities in Acceptance of Deceased Donor Kidneys Between the United States and France and Estimated Effects of Increased US Acceptance
Using a new approach based on validated analytical methods and computer simulations, this work revealed that French transplant centres are much more likely to transplant kidneys from older donors than their American counterparts, and that this effectively increases the number of patients transplanted.
During the event, a specific symposium is held for the EU Train-ESOT that highlights the methodological and statistical risks clinical researchers can face in the field of transplantation. Carmen Lefaucheur, Olivier Aubert, Alexandre Loupy, Yassine Bouatou, Dany Anglicheau and Christophe Legendre are invited to speak during this event to present the future of patient care in transplantation.
Check the poster submitted by Marc Raynaud here.
You can follow the event through social media with the hashtag #ESOT2019 and @ParisTxGroup.
Archetype Analysis Identifies Distinct Profiles in Renal Transplant Recipients with Transplant Glomerulopathy Associated with Allograft Survival
New research conducted by the Paris Translational Research Center for Organ Transplantation team could help clinicians determine which patients will have a disease that usually occurs after a kidney transplant and which are at high risk of transplant failure. The results are published today in the prestigious Journal of the American Society of Nephrology (JASN).
Transplant glomerulopathy was first described and characterized 50 years ago. It is a disease associated with the loss of a kidney transplant and common after a transplant. It affects the functional units (i. e. glomeruli) of the transplanted kidney. There is currently no treatment for this heterogeneous disease.
This year, the BANFF Foundation for Allograft Pathology partners up with the American Society of Histocompatibility and Immunogenetics (ASHI) for a joint scientific meeting. Which will take place between the 23rd and the 27th of September in Pittsburgh, USA. Dr. Alexandre Loupy will be present there as part of the ASHI/BANFF Steering Committee.
Abstract submissions are now open for oral and poster presentations. The deadline for the submission is the 8th of April.
During the meeting, you will be able to meet more than 1 200 professionals in HLA and the transplant field. And discover all the latest updates in immunogenetics and transplant immunology.
The BANFF Foundation for Allograft Pathology is a non-profit foundation, established in 2013. BANFF aims to further the development of the international BANFF Classification of Allograft Pathology, as well as publicize it. They also aspire to ease collaborative research in order to improve the care of transplant patient.
ASHI was founded in 1974, it is a non-profit international organization of clinical and research professionals. ASHI aims to advance the science and application of histocompatibility and immunogenetics. They also want to provide a forum for the exchange of information among scientists.
Paris Transplant Group
Our global aim is to accelerate the translation of immunological and gene expression discoveries into the clinical field by filling the gap between basic science and applied biomedical researches.