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Dynamic prediction of renal survival among deeply phenotyped kidney transplant recipients using artificial intelligence: an observational, international, multicohort study

10/27/2021

 
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For individuals with end-stage renal disease, kidney transplantation is the best treatment, in terms of quality and quantity of life and costs for society. Considering the organ shortage worldwide, the allograft failure is a real burden in chronic kidney disease, contributing to the growing number of the seven million individuals with end-stage renal disease. For these reasons, health agencies such as the Food and Drug Administation and the European Medicines Agency, have emphasized the need for developing a prediction model that would accurately predict the risk of allograft failure, which would allow clinicians to continuously enhance their prognostic judgements, and adapt the patient monitoring and management.

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M. Raynaud wins the Leonardo Da Vinci Award at ESOT 2021

9/2/2021

 
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​The Leonardo Da Vinci Transplant Research Innovation Award is the most prestigious scientific award at the ESOT Congress, stimulating an unprecedented and innovative approach to research. There are two winners of this award; one for clinical research and one for basic or translational science.

𝗠𝗮𝗿𝗰 𝗥𝗮𝘆𝗻𝗮𝘂𝗱 won the clinical science award and 𝗡𝗶𝗰𝗼𝗹𝗮 𝗱𝗲 𝗦𝘁𝗲𝗳𝗮𝗻𝗼 for picked up the basic science prize!
Marc Raynaud’s research focused on ‘𝘋𝘺𝘯𝘢𝘮𝘪𝘤 𝘱𝘳𝘦𝘥𝘪𝘤𝘵𝘪𝘰𝘯 𝘰𝘧 𝘬𝘪𝘥𝘯𝘦𝘺-𝘨𝘳𝘢𝘧𝘵 𝘴𝘶𝘳𝘷𝘪𝘷𝘢𝘭 𝘸𝘪𝘵𝘩 𝘢𝘳𝘵𝘪𝘧𝘪𝘤𝘪𝘢𝘭 𝘪𝘯𝘵𝘦𝘭𝘭𝘪𝘨𝘦𝘯𝘤𝘦: 𝘈𝘯 𝘪𝘯𝘵𝘦𝘳𝘯𝘢𝘵𝘪𝘰𝘯𝘢𝘭 𝘴𝘵𝘶𝘥𝘺 𝘰𝘧 𝘥𝘦𝘦𝘱 𝘤𝘰𝘩𝘰𝘳𝘵𝘴 𝘰𝘧 𝘬𝘪𝘥𝘯𝘦𝘺 𝘳𝘦𝘤𝘪𝘱𝘪𝘦𝘯𝘵𝘴’, whilst Nicola de Stefano presented the study: ‘𝘌𝘹𝘵𝘳𝘢𝘤𝘦𝘭𝘭𝘶𝘭𝘢𝘳 𝘷𝘦𝘴𝘪𝘤𝘭𝘦𝘴 𝘧𝘳𝘰𝘮 𝘩𝘶𝘮𝘢𝘯 𝘭𝘪𝘷𝘦𝘳 𝘴𝘵𝘦𝘮 𝘤𝘦𝘭𝘭𝘴 𝘳𝘦𝘥𝘶𝘤𝘦 𝘪𝘯𝘫𝘶𝘳𝘺 𝘪𝘯 𝘢 𝘮𝘰𝘥𝘦𝘭 𝘰𝘧 𝘯𝘰𝘳𝘮𝘰𝘵𝘩𝘦𝘳𝘮𝘪𝘤 𝘱𝘦𝘳𝘧𝘶𝘴𝘪𝘰𝘯 𝘰𝘧 𝘳𝘢𝘵 𝘪𝘴𝘤𝘩𝘦𝘮𝘪𝘤 𝘭𝘪𝘷𝘦𝘳’.

Paris Transplant Group won the Stronger Together PRO Award at ESOT 2021

8/31/2021

 
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For the 3rd time in a row, the Paris Transplant Group has won the Stronger Together PRO Award at ESOT congress! The Stronger Together PRO Award is presented to the group of abstracts submitted by a single organisation with the best average score (minimum of five abstracts submitted by the institution). 
ESOT President Vassilios Papalois explained, “The award not only rewards the quality of science, but also the quality of teamwork within a transplant group.”
​
“We are really honoured and proud to receive this award”, explained Alexandre Loupy. “As a team, we are all looking into the same direction in trying to improve patient outcomes”.

This is the third time the Transplant Research Group has won this prestigious award, who will be awarded a €5,000 prize.

PTG at ESOT 2021

8/24/2021

 
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From 29th August to 1st September 2021, the Paris Transplant Group joins the 20th edition of the European Society for Organ Transplantation’s (ESOT) biennial congress in Milano.
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Many members of the Paris Transplant Group are attending the event. Especially, do not miss the plenary presentation of Alexandre Loupy about “Fine-tuning endpoints in specific transplant settings”.

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V. Goutaudier is honoured with a grant from the Fondation pour la Recherche Médicale

7/23/2021

 
Would a better analysis of biopsies ensure better survival of kidney grafts in transplanted patients? This is the question Valentin Goutaudier, a researcher at the Paris Transplant Group, is challenging. To explore this question, he will receive a grant from the Fondation pour la Recherche Médicale for his thesis "Precision diagnosis of rejection in renal transplantation: a multidimensional transcriptomic approach."
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With the support of the Foundation, Valentin Goutaudier will seek to develop biomarkers of histological lesions related to graft rejection using a transcriptomic approach. Indeed, transcriptomic analysis of biopsies from the standard monitoring process of transplant patients, is now routinely possible thanks to the Nanostring® technology. This analysis system is capable of quantifying up to 800 nucleic acids from biopsy tissue. This information was previously unavailable due to the degradation of the tissue during the fixation process.
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Marc Raynaud's Ph.D. DEFENSE

2/25/2021

 
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Marc Raynaud defended his PhD on biostatistics on February 2021.
He presented his research on r
isk prediction and prognostic score development in kidney transplantation. Congratulation to him. 
#proud #strongertogether #datapower

Open position: RESEARCH ENGINEER IN CHARGE OF TRANSCRIPTOMICS PLATFORM (FR)

1/13/2021

 
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L’équipe 11 du Pr Alexandre Loupy, localisée au PARCC INSERM U970 à Paris, est spécialisée dans la transplantation d’organes solides via des approches épidémiologiques et bioinformatiques. Les buts principaux de l’équipe sont notamment d’accélérer la transition des découvertes en sciences fondamentales et en génétique vers leurs applications en clinique, d’améliorer la stratification du risque et de mieux classifier les phénomènes de rejets en transplantation d’organe par une approche médicale personnalisée. En collaboration avec plusieurs hôpitaux français et internationaux, la plateforme transcriptomique du PARCC est en plein développement sur de nombreux sujets de recherche autour de la transplantation d’organes solides.

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COVID-19-related medical research: a meta-research and critical appraisal

1/12/2021

 
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As with many fields, science has been put to the test by the coronavirus pandemic. An international team of researchers, led by French scientists, has demonstrated novel scientific practices around Covid-19. Under the pressure of the number of cases and the urgent need to understand the virus, many research groups have shared results, sometimes to the expense of high scientific standards.

During the first wave of the Covid-19 epidemic, medical research saw a historic number of studies on the coronavirus published in a short period of time. An international consortium of experts in medical methodology undertook the major challenge of evaluating the Covid-19 research during this first wave.

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A. Loupy, Awarded GENEWIZ Digital Spatial Profiler Grant

1/7/2021

 
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Leading global genomics service provider, GENEWIZ, a Brooks Life Sciences Company, announced today that Alexandre Loupy, MD, Ph.D., Professor of Nephrology and Epidemiology at Necker Hospital, Paris, and Director of the Paris Transplant Group at Inserm, France, has been awarded the GENEWIZ Digital Spatial Profiler Grant. Pr. Loupy will be provided digital spatial profiling services on the NanoString Technologies® GeoMx™ platform for his study investigating the spatial immune response during allograft rejection.

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Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the US

12/15/2020

 
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New research indicates that analyses of kidney biopsies from deceased donors don’t provide meaningful information beyond standard assessments of donor and recipient characteristics. In addition, the study revealed that relying on these analyses has prompted the discard of many potentially suitable organs for transplantation in the United States. The findings appear in JASN.

Despite a critical scarcity of organs available for transplantation, thousands of deceased donor kidneys are discarded each year in the United States. 


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G. Coutance, laureate of the University Doctorate Thesis Award

12/14/2020

 
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In order to encourage the quality of PhD theses, the French Society of Cardiology's Think Tank on Cardiovascular Research (GRRC) awards two University Thesis Prizes each year.

​Guillaume Coutance receives this award for his thesis entitled: Allo-immunisation and allograft rejection in heart transplantation: from diagnosis to clinical consequences. 

Alexandre Loupy, laureate of the Health Innovator Awards 2020

12/11/2020

 
In December 2020, Alexandre Loupy was awarded the Health Innovator Awards (Prix des Innovateurs en santé) 2020 by the Ile de France region. This award distinguishes 3 researchers from the Paris area and their teams for their scientific innovations with a medical, societal or public health impact. 

​Alexandre Loupy is rewarded for his discoveries in the field of transplantation and transplant rejection as well as the deployment of AI based algorithms to improve clinical trials, fast-track drug discoveries and improve patient care
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Open position: Clinical Research Assistant (FR)

11/28/2020

 
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Ce poste de technicien d'étude clinique est à pourvoir au sein de l’unité de recherche INSERM U970 dans l’équipe 11 : Approches multidimensionnelles en transplantation d’organes dirigée par le Pr Alexandre Loupy.
Ce poste s’intègre au sein d’un projet se focalisant sur la transplantation pulmonaire. Actuellement, la prédiction du succès ou de l’échec d’une greffe pulmonaire reste difficile car les mécanismes immunologiques autour d’un greffon sont mal connus.
Notre équipe s’intéresse aux approches personnalisées pour la prédiction de risque post-transplantation (notamment les risques de survenue de rejet) par l’intégration d’informations multidimensionnelles. Cela regroupe des données provenant de la clinique, de l’histologie classique, de la biologie et éventuellement des données provenant de technologies innovantes en immunologie, biologie moléculaire, génétique et biomarqueurs.

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Open position: Clinical Research Assistant (FR)

11/28/2020

 
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Ce poste d'assistant de recherche clinique est à pourvoir au sein de l’unité de recherche INSERM U970 dans l’équipe 11 : Approches multidimensionnelles en transplantation d’organes dirigée par le Pr Alexandre Loupy.
Notre équipe s’intéresse aux approches personnalisées en médecine de la transplantation par l’intégration d’informations multidimensionnelles provenant de l’histologie classique, de la biologie et de la science clinique ainsi que des informations nouvelles provenant de technologies innovantes en immunologie, biologie moléculaire, génétique et biomarqueurs.
Ce poste s’intègre dans le cadre d’un nouveau projet se focalisant sur la transplantation hépatique ayant pour objectifs : de précision diagnostique et la stratification du rejet en transplantation hépatique.

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Charlotte Debiais' M.D. defense

11/2/2020

 
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Charlotte Debiais defended her M.D on October 30, 2020. She presented her study on the determinants of mortality after kidney transplant and on the construction of a predictive model for kidney transplant recipient mortality.
​She already defended a doctorate in veterinary medicine in 2011 and she is now starting a PhD in epidemiology and biostatistics with PTG.
#proud #strongertogether #loveresearch

A. Loupy, recipient of the 2020 Paul I. Terasaki Clinical Science Award

10/7/2020

 
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The Paul I. Terasaki Clinical Science Award was established by the American Society for Histocompatibility and Immunogenetics in 2003. It aims to recognize significant contributions to the fields of clinical transplantation, histocompatibility, and immunogenetics. 
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​The 2020 Paul I. Terasaki Clinical Science Award is awarded to Alexandre Loupy. Thus, he will give a special lecture during the 2020 virtual ASHI Annual Meeting to be held online on October 19-23, 2020.

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Thank you to our Clinical Research Assistants

9/30/2020

 
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We would like to thank our team of Clinical Research Assistants, who work hard to make the grants running in Necker and Saint Louis hospitals, and provide quality data to the PTG.
​From left to right: Francine, Ouardia, Safia, Célia, Fatima, Marie, Julie, Aliaume, and Jessy.
​Meet the complete team here.

The Banff 2019 Kidney Meeting Reports

9/20/2020

 
The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of the American Society for Histocompatibility and Immunogenetics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification, advances from the Banff working groups, and standardization of molecular diagnostics. 

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PTG at TTS 2020

9/6/2020

 
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​Every year, The Transplantation Society (TTS) gathers experts of organ transplantation from all over the world at the occasion of its annual congress. For the 2020 edition, due to sanitary concerns, the congress will take place virtually. The event starts on 13 September 2020 for 4 days of live broadcasts.

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Open Position: Data scientist / Data analyst

8/4/2020

 
The Paris Transplant Group in Paris, France, is seeking a data scientist/analyst in the field of solid organ transplantation.
​

The data scientist/analyst is a resource who makes value out of data. Such a person proactively fetches information from various sources and analyzes it for better understanding about how the clinical activity and patient’s follow-up perform, and to build AI tools that automate certain processes regarding data treatment. He/she also who subscribes to the vision of the importance of scientific thinking and is keen to apply it to real-world challenges.
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His/her duties will include creating various machine learning-based tools or processes within the team, such as recommendation engines or automated lead scoring systems. The resource within this role should also be able to perform statistical analysis. You are detail-oriented, meticulous, and an analytical team player. You ask the right questions, effectively communicate across teams, and want an opportunity to help shape what data can offer to our knowledge of organ transplantation.

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Open Position: Clinical Research Assistant

8/4/2020

 
The Paris Transplant Group in Paris, France, is seeking a research assistant for our research program. This program conducts databases and other clinical researches in solid organ transplant patients.

​The assistant will work under the supervision of the PTG team leader (PI) and project manager to fulfil research-related responsibilities in a professional and ethical manner. The assistant will work with a team of research staff, administrative staff, physicians, nurses and liaise with other healthcare professionals to ensure that each project is conducted to meet the deadlines. This position requires contact with physicians, nurses, pharmacists, and other hospital staff. Strong communication and interpersonal skills are essential.
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Statistical performance of 16 posttransplant risk scores in a contemporary cohort of heart transplant recipients

7/28/2020

 
Accurate risk stratification of early heart transplant failure is required to avoid futile transplants and rationalize donor selection. We aimed to evaluate the statistical performance of existing risk scores on a contemporary cohort of heart transplant recipients.

After an exhaustive search, we identified 16 relevant risk scores. From the UNOS database, we selected all first noncombined adult heart transplants performed between 2014 and 2017 for validation. The primary endpoint was death or retransplant during the first year posttransplant.

​For all scores, we analyzed their association with outcomes, sensitivity, specificity, likelihood ratios, and discrimination (concordance index and overlap of individual scores). The cohort included 9396 patients. All scores were significantly associated with the primary outcome (P < .001 for all scores). Their likelihood ratios, both negative and positive, were poor. The discriminative performance of all scores was limited, with concordance index ranging from 0.544 to 0.646 (median 0.594) and an important overlap of individual scores between patients with or without the primary endpoint. Subgroup analyses revealed important variation in discrimination according to donor age, recipient age, and the type of assist device used at transplant.

Our findings raise concerns about the use of currently available scores in the clinical field.

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PTG at the ATC’s 2020 Virtual Congress

5/29/2020

 
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Every year, the American Transplant Congress (ATC) gathers experts of organ transplantation from all over the world. For the 2020 edition, due to sanitary concerns and travel regulations, the in-person ATC initially planned in Philadelphia has been cancelled and replaced by a Virtual Congress. The event starts on 30 May 2020 for 3 days of live broadcasts.
The topic of ATC 2020 is “The Science of Tomorrow Starts Today” and covers the latest research in the field of transplantation. It showcases the research done in the industry too.

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A considerable decline in the number of organ transplants since the start of the COVID-19 pandemic in France and the US

5/12/2020

 
​​A French-American study conducted by researchers from the Paris Transplant Group (University of Paris, Inserm and AP-HP) just published in The Lancet reveals a more than 90% drop in the number of organ procurement and transplants during the COVID-19 pandemic in France. The trend, which is also continuing across the Atlantic, poses a life-threatening risk to the thousands of people waiting for transplants in France and the United States.
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Identification and characterization of trajectories of cardiac allograft vasculopathy after heart transplantation

5/4/2020

 
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Every year, tens of thousands of deaths are due to end-stage heart failure in Europe and in the US combined. Heart transplantation is the ultimate treatment, but its number is dramatically limited due to the shortage of organs in those countries. 
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​In the same time, the chances of survival beyond one year after transplantation have remained unchanged in recent years, despite significant progress in immunosuppressive therapy and patient care.
One of the most common reasons for long-term graft failure and patient death is an accelerated form of coronary artery disease called cardiac allograft vasculopathy. It is a frequent complication that affects up to half of patients within 10 years following heart transplantation. Yet, until now, little has been known about the different evolutive profiles of cardiac allograft vasculopathy and their risk factors.

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