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Dynamic prediction of renal survival among deeply phenotyped kidney transplant recipients using artificial intelligence: an observational, international, multicohort study

10/27/2021

 
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For individuals with end-stage renal disease, kidney transplantation is the best treatment, in terms of quality and quantity of life and costs for society. Considering the organ shortage worldwide, the allograft failure is a real burden in chronic kidney disease, contributing to the growing number of the seven million individuals with end-stage renal disease. For these reasons, health agencies such as the Food and Drug Administation and the European Medicines Agency, have emphasized the need for developing a prediction model that would accurately predict the risk of allograft failure, which would allow clinicians to continuously enhance their prognostic judgements, and adapt the patient monitoring and management.

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Paris Transplant Group won the Stronger Together PRO Award at ESOT 2021

8/31/2021

 
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For the 3rd time in a row, the Paris Transplant Group has won the Stronger Together PRO Award at ESOT congress! The Stronger Together PRO Award is presented to the group of abstracts submitted by a single organisation with the best average score (minimum of five abstracts submitted by the institution). 
ESOT President Vassilios Papalois explained, “The award not only rewards the quality of science, but also the quality of teamwork within a transplant group.”
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“We are really honoured and proud to receive this award”, explained Alexandre Loupy. “As a team, we are all looking into the same direction in trying to improve patient outcomes”.

This is the third time the Transplant Research Group has won this prestigious award, who will be awarded a €5,000 prize.

PTG at ESOT 2021

8/24/2021

 
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From 29th August to 1st September 2021, the Paris Transplant Group joins the 20th edition of the European Society for Organ Transplantation’s (ESOT) biennial congress in Milano.
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Many members of the Paris Transplant Group are attending the event. Especially, do not miss the plenary presentation of Alexandre Loupy about “Fine-tuning endpoints in specific transplant settings”.

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COVID-19-related medical research: a meta-research and critical appraisal

1/12/2021

 
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As with many fields, science has been put to the test by the coronavirus pandemic. An international team of researchers, led by French scientists, has demonstrated novel scientific practices around Covid-19. Under the pressure of the number of cases and the urgent need to understand the virus, many research groups have shared results, sometimes to the expense of high scientific standards.

During the first wave of the Covid-19 epidemic, medical research saw a historic number of studies on the coronavirus published in a short period of time. An international consortium of experts in medical methodology undertook the major challenge of evaluating the Covid-19 research during this first wave.

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A. Loupy, Awarded GENEWIZ Digital Spatial Profiler Grant

1/7/2021

 
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Leading global genomics service provider, GENEWIZ, a Brooks Life Sciences Company, announced today that Alexandre Loupy, MD, Ph.D., Professor of Nephrology and Epidemiology at Necker Hospital, Paris, and Director of the Paris Transplant Group at Inserm, France, has been awarded the GENEWIZ Digital Spatial Profiler Grant. Pr. Loupy will be provided digital spatial profiling services on the NanoString Technologies® GeoMx™ platform for his study investigating the spatial immune response during allograft rejection.

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Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the US

12/15/2020

 
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New research indicates that analyses of kidney biopsies from deceased donors don’t provide meaningful information beyond standard assessments of donor and recipient characteristics. In addition, the study revealed that relying on these analyses has prompted the discard of many potentially suitable organs for transplantation in the United States. The findings appear in JASN.

Despite a critical scarcity of organs available for transplantation, thousands of deceased donor kidneys are discarded each year in the United States. 


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Alexandre Loupy, laureate of the Health Innovator Awards 2020

12/11/2020

 
In December 2020, Alexandre Loupy was awarded the Health Innovator Awards (Prix des Innovateurs en santé) 2020 by the Ile de France region. This award distinguishes 3 researchers from the Paris area and their teams for their scientific innovations with a medical, societal or public health impact. 

​Alexandre Loupy is rewarded for his discoveries in the field of transplantation and transplant rejection as well as the deployment of AI based algorithms to improve clinical trials, fast-track drug discoveries and improve patient care
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A. Loupy, recipient of the 2020 Paul I. Terasaki Clinical Science Award

10/7/2020

 
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The Paul I. Terasaki Clinical Science Award was established by the American Society for Histocompatibility and Immunogenetics in 2003. It aims to recognize significant contributions to the fields of clinical transplantation, histocompatibility, and immunogenetics. 
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​The 2020 Paul I. Terasaki Clinical Science Award is awarded to Alexandre Loupy. Thus, he will give a special lecture during the 2020 virtual ASHI Annual Meeting to be held online on October 19-23, 2020.

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The Banff 2019 Kidney Meeting Reports

9/20/2020

 
The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of the American Society for Histocompatibility and Immunogenetics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification, advances from the Banff working groups, and standardization of molecular diagnostics. 

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PTG at TTS 2020

9/6/2020

 
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​Every year, The Transplantation Society (TTS) gathers experts of organ transplantation from all over the world at the occasion of its annual congress. For the 2020 edition, due to sanitary concerns, the congress will take place virtually. The event starts on 13 September 2020 for 4 days of live broadcasts.

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Statistical performance of 16 posttransplant risk scores in a contemporary cohort of heart transplant recipients

7/28/2020

 
Accurate risk stratification of early heart transplant failure is required to avoid futile transplants and rationalize donor selection. We aimed to evaluate the statistical performance of existing risk scores on a contemporary cohort of heart transplant recipients.

After an exhaustive search, we identified 16 relevant risk scores. From the UNOS database, we selected all first noncombined adult heart transplants performed between 2014 and 2017 for validation. The primary endpoint was death or retransplant during the first year posttransplant.

​For all scores, we analyzed their association with outcomes, sensitivity, specificity, likelihood ratios, and discrimination (concordance index and overlap of individual scores). The cohort included 9396 patients. All scores were significantly associated with the primary outcome (P < .001 for all scores). Their likelihood ratios, both negative and positive, were poor. The discriminative performance of all scores was limited, with concordance index ranging from 0.544 to 0.646 (median 0.594) and an important overlap of individual scores between patients with or without the primary endpoint. Subgroup analyses revealed important variation in discrimination according to donor age, recipient age, and the type of assist device used at transplant.

Our findings raise concerns about the use of currently available scores in the clinical field.

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A considerable decline in the number of organ transplants since the start of the COVID-19 pandemic in France and the US

5/12/2020

 
​​A French-American study conducted by researchers from the Paris Transplant Group (University of Paris, Inserm and AP-HP) just published in The Lancet reveals a more than 90% drop in the number of organ procurement and transplants during the COVID-19 pandemic in France. The trend, which is also continuing across the Atlantic, poses a life-threatening risk to the thousands of people waiting for transplants in France and the United States.
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Identification and characterization of trajectories of cardiac allograft vasculopathy after heart transplantation

5/4/2020

 
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Every year, tens of thousands of deaths are due to end-stage heart failure in Europe and in the US combined. Heart transplantation is the ultimate treatment, but its number is dramatically limited due to the shortage of organs in those countries. 
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​In the same time, the chances of survival beyond one year after transplantation have remained unchanged in recent years, despite significant progress in immunosuppressive therapy and patient care.
One of the most common reasons for long-term graft failure and patient death is an accelerated form of coronary artery disease called cardiac allograft vasculopathy. It is a frequent complication that affects up to half of patients within 10 years following heart transplantation. Yet, until now, little has been known about the different evolutive profiles of cardiac allograft vasculopathy and their risk factors.

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Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study

3/3/2020

 
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The first universal algorithm for predicting the risk of kidney transplant loss, named iBox, has been developed, validated and just made public by teams from Europe and the US.

​The iBox is designed for clinicians to personalize and improve patient follow-up. The iBox could also accelerate the development of new immunosuppressive treatments by reducing the duration of clinical trials and defining a valid surrogate endpoint.
Chronic kidney disease affects 1 out of 10 people worldwide and is steadily increasing. When it reaches end-stage renal disease and endangers the lives of patients, dialysis or transplantation is required. ​

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Paris Transplant Group at the SFT congress 2019

12/2/2019

 
The members of the Paris Transplant Group are present at the SFT congress which will take place from December 3, 2019 in Bordeaux, France.
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Many lectures by the Paris Transplant Group are planned to present the ongoing research to the French transplant community. The presentations will cover:
  • The latest results of clinical research, including the TRANSFORM study carried out with Novartis,
  • Research on transplant prognosis for improved patient follow-up, including the iBox algorithm.
  • Advances made in understanding the mechanisms at work in the event of rejection or unsuccessful transplantation. 
This research covers kidney, lung and other transplantation.

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KIDNEY WEEK 2019: PTG at ASN meeting 2019

10/15/2019

 
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The Kidney Week is a periodic and international ASN meeting that gathers thousands of kidney professionals from across the globe. For the 2019 event, the event is held in Washington, DC between the 5th to the 10th of November 2019. 

Three of the Paris Transplant Group members will have the opportunities to present the latest results of the Group including the latest published information about the iBox algorithm.

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Presentation to nobel laureate Alvin Roth

9/20/2019

 
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Alexandre Loupy gave a lecture at Stanford University at the invitation of the Nobel Prize laureate Alvin Roth. To the audience, including F Javier Carmona, Alexandre Loupy presented the transplantation allocation systems and the iBox results recently published in BMJ.

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PTG awarded the ESOT StrongeR Together Pro Award

9/16/2019

 
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The team of the Paris Transplant Group has been awarded at the ESOT 2019 congress in Copenhagen for its many contribution in the field of transplantation. 

The Prize is given to a single Institution having submitted at least 5 abstracts for the event and granted with the best score. The Paris Transplant Group is very pleased to won this European award twice in a row. 

Check out the contribution submitted by the Group on the ESOT website: esotcongress.org.

Disparities in Acceptance of Deceased Donor Kidneys Between the United States and France and Estimated Effects of Increased US Acceptance

8/26/2019

 
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New publication in JAMA Internal Medicine: The first international analysis of renal transplant patient data shows that a change in allocation criteria in the United States could benefit patients on the waiting list. Thousands more kidneys could be transplanted each year if the United States used, as France does, kidneys from older donors.
Nearly 5,000 people in the United States and 3,500 in Europe die each year waiting for a kidney transplant. Yet, over the same period, in the United States, more than 3,500 available kidneys were discarded. The Journal of the American Medical Association (JAMA) Internal Medicine today published our results, obtained with the help of an international team, that compared the use of kidneys available in the United States and France between 2004 and 2014. ​
Using a new approach based on validated analytical methods and computer simulations, this work revealed that French transplant centres are much more likely to transplant kidneys from older donors than their American counterparts, and that this effectively increases the number of patients transplanted. 

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PTG at ESOT2019

6/18/2019

 
From 15 to 18 September 2019 the annual event of the European Society for Organ Transplantation (ESOT) takes place in Copenhagen.

ESOT is the European umbrella organisation under which all European transplant professionals are organized. The organisation trains and supports its members through various European programmes and events, such as the 2019 event in Copenhagen.
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During the event, a specific symposium is held for the EU Train-ESOT that highlights the methodological and statistical risks clinical researchers can face in the field of transplantation. Carmen Lefaucheur, Olivier Aubert, Alexandre Loupy, Yassine Bouatou, Dany Anglicheau and Christophe Legendre are invited to speak during this event to present the future of patient care in transplantation.
Check the poster submitted by Marc Raynaud here. 

You can follow the event through social media with the hashtag #ESOT2019 and @ParisTxGroup.

PTG at the 2019 ATC in Boston

5/14/2019

 
The American Transplant Congress, or ATC, is the not-to-be-missed event to exchange new scientific and clinical information from the field of transplantation.

​Each year, transplant physicians, scientists, nurses, organ procurement personnel, pharmacists, allied health professionals, and other transplant professionals gather in this congress organized by the American Society of Transplant Surgeons and the American Society of Transplantation.
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All aboard the EU-TRAIN at ESOT2019

5/2/2019

 
The first EU TRAIN – ESOT symposium takes place at the ESOT2019 Congress in Copenhagen.

This is a unique opportunity to “get on board” the EU-TRAIN, the European Transplantation and Innovation Consortium for Risk Stratification in Kidney Transplant Patients. 
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The symposium will not only introduce the consortium, but it will also focus on the methodological and statistical pitfalls clinical researchers can face in the field of transplantation.
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Archetype Analysis Identifies Distinct Profiles in Renal Transplant Recipients with Transplant Glomerulopathy Associated with Allograft Survival

3/14/2019

 
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New research conducted by the Paris Translational Research Center for Organ Transplantation team could help clinicians determine which patients will have a disease that usually occurs after a kidney transplant and which are at high risk of transplant failure. The results are published today in the prestigious Journal of the American Society of Nephrology (JASN).

Transplant glomerulopathy was first described and characterized 50 years ago. It is a disease associated with the loss of a kidney transplant and common after a transplant. It affects the functional units (i. e. glomeruli) of the transplanted kidney. There is currently no treatment for this heterogeneous disease.

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The 2019 BANFF Meeting

2/27/2019

 
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This year, the BANFF Foundation for Allograft Pathology partners up with the American Society of Histocompatibility and Immunogenetics (ASHI) for a joint scientific meeting. Which will take place between the 23rd and the 27th of September in Pittsburgh, USA. Dr. Alexandre Loupy will be present there as part of the ASHI/BANFF Steering Committee.
Abstract submissions are now open for oral and poster presentations. The deadline for the submission is the 8th of April.

During the meeting, you will be able to meet more than 1 200 professionals in HLA and the transplant field. And discover all the latest updates in immunogenetics and transplant immunology.

The BANFF Foundation for Allograft Pathology is a non-profit foundation, established in 2013. BANFF aims to further the development of the international BANFF Classification of Allograft Pathology, as well as publicize it. They also aspire to ease collaborative research in order to improve the care of transplant patient.

ASHI was founded in 1974, it is a non-profit international organization of clinical and research professionals. ASHI aims to advance the science and application of histocompatibility and immunogenetics. They also want to provide a forum for the exchange of information among scientists.

Alexandre Loupy, winner of the 2018 National Academy of Medicine Award

12/19/2018

 
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On December 18, 2018, Dr. Alexandre Loupy was awarded the National Academy of Medicine Award for his work on "Renal transplantation, anti-HLA graft rejection, and biomarker identification".

This is the first time he has received a national award for his research in France. They have made it possible to develop the international classification of graft rejection in recent years. With the goal of improving the management of transplant patients.

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