Category: Jean Philippe Empana

Identification and characterization of trajectories of cardiac allograft vasculopathy after heart transplantation

5/4/2020

Every year, tens of thousands of deaths are due to end-stage heart failure in Europe and in the US combined. Heart transplantation is the ultimate treatment, but its number is dramatically limited due to the shortage of organs in those countries.

In the same time, the chances of survival beyond one year after transplantation have remained unchanged in recent years, despite significant progress in immunosuppressive therapy and patient care.

One of the most common reasons for long-term graft failure and patient death is an accelerated form of coronary artery disease called cardiac allograft vasculopathy. It is a frequent complication that affects up to half of patients within 10 years following heart transplantation. Yet, until now, little has been known about the different evolutive profiles of cardiac allograft vasculopathy and their risk factors.

Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study

3/3/2020

The first universal algorithm for predicting the risk of kidney transplant loss, named iBox, has been developed, validated and just made public by teams from Europe and the US.

The iBox is designed for clinicians to personalize and improve patient follow-up. The iBox could also accelerate the development of new immunosuppressive treatments by reducing the duration of clinical trials and defining a valid surrogate endpoint.

Chronic kidney disease affects 1 out of 10 people worldwide and is steadily increasing. When it reaches end-stage renal disease and endangers the lives of patients, dialysis or transplantation is required.

Identification and characterization of trajectories of cardiac allograft vasculopathy after heart transplantation

Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study

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