Category: Marc Raynaud

Dynamic prediction of renal survival among deeply phenotyped kidney transplant recipients using artificial intelligence: an observational, international, multicohort study

10/27/2021

For individuals with end-stage renal disease, kidney transplantation is the best treatment, in terms of quality and quantity of life and costs for society. Considering the organ shortage worldwide, the allograft failure is a real burden in chronic kidney disease, contributing to the growing number of the seven million individuals with end-stage renal disease. For these reasons, health agencies such as the Food and Drug Administation and the European Medicines Agency, have emphasized the need for developing a prediction model that would accurately predict the risk of allograft failure, which would allow clinicians to continuously enhance their prognostic judgements, and adapt the patient monitoring and management.

M. Raynaud wins the Leonardo Da Vinci Award at ESOT 2021

9/2/2021

The Leonardo Da Vinci Transplant Research Innovation Award is the most prestigious scientific award at the ESOT Congress, stimulating an unprecedented and innovative approach to research. There are two winners of this award; one for clinical research and one for basic or translational science.

𝗠𝗮𝗿𝗰 𝗥𝗮𝘆𝗻𝗮𝘂𝗱 won the clinical science award and 𝗡𝗶𝗰𝗼𝗹𝗮 𝗱𝗲 𝗦𝘁𝗲𝗳𝗮𝗻𝗼 for picked up the basic science prize!

Marc Raynaud’s research focused on ‘𝘋𝘺𝘯𝘢𝘮𝘪𝘤 𝘱𝘳𝘦𝘥𝘪𝘤𝘵𝘪𝘰𝘯 𝘰𝘧 𝘬𝘪𝘥𝘯𝘦𝘺-𝘨𝘳𝘢𝘧𝘵 𝘴𝘶𝘳𝘷𝘪𝘷𝘢𝘭 𝘸𝘪𝘵𝘩 𝘢𝘳𝘵𝘪𝘧𝘪𝘤𝘪𝘢𝘭 𝘪𝘯𝘵𝘦𝘭𝘭𝘪𝘨𝘦𝘯𝘤𝘦: 𝘈𝘯 𝘪𝘯𝘵𝘦𝘳𝘯𝘢𝘵𝘪𝘰𝘯𝘢𝘭 𝘴𝘵𝘶𝘥𝘺 𝘰𝘧 𝘥𝘦𝘦𝘱 𝘤𝘰𝘩𝘰𝘳𝘵𝘴 𝘰𝘧 𝘬𝘪𝘥𝘯𝘦𝘺 𝘳𝘦𝘤𝘪𝘱𝘪𝘦𝘯𝘵𝘴’, whilst Nicola de Stefano presented the study: ‘𝘌𝘹𝘵𝘳𝘢𝘤𝘦𝘭𝘭𝘶𝘭𝘢𝘳 𝘷𝘦𝘴𝘪𝘤𝘭𝘦𝘴 𝘧𝘳𝘰𝘮 𝘩𝘶𝘮𝘢𝘯 𝘭𝘪𝘷𝘦𝘳 𝘴𝘵𝘦𝘮 𝘤𝘦𝘭𝘭𝘴 𝘳𝘦𝘥𝘶𝘤𝘦 𝘪𝘯𝘫𝘶𝘳𝘺 𝘪𝘯 𝘢 𝘮𝘰𝘥𝘦𝘭 𝘰𝘧 𝘯𝘰𝘳𝘮𝘰𝘵𝘩𝘦𝘳𝘮𝘪𝘤 𝘱𝘦𝘳𝘧𝘶𝘴𝘪𝘰𝘯 𝘰𝘧 𝘳𝘢𝘵 𝘪𝘴𝘤𝘩𝘦𝘮𝘪𝘤 𝘭𝘪𝘷𝘦𝘳’.

PTG at ESOT 2021

8/24/2021

From 29th August to 1st September 2021, the Paris Transplant Group joins the 20th edition of the European Society for Organ Transplantation’s (ESOT) biennial congress in Milano.

Many members of the Paris Transplant Group are attending the event. Especially, do not miss the plenary presentation of Alexandre Loupy about “Fine-tuning endpoints in specific transplant settings”.

Marc Raynaud's Ph.D. DEFENSE

2/25/2021

Marc Raynaud defended his PhD on biostatistics on February 2021.
He presented his research on risk prediction and prognostic score development in kidney transplantation. Congratulation to him.
#proud #strongertogether #datapower

COVID-19-related medical research: a meta-research and critical appraisal

1/12/2021

As with many fields, science has been put to the test by the coronavirus pandemic. An international team of researchers, led by French scientists, has demonstrated novel scientific practices around Covid-19. Under the pressure of the number of cases and the urgent need to understand the virus, many research groups have shared results, sometimes to the expense of high scientific standards.

During the first wave of the Covid-19 epidemic, medical research saw a historic number of studies on the coronavirus published in a short period of time. An international consortium of experts in medical methodology undertook the major challenge of evaluating the Covid-19 research during this first wave.

Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the US

12/15/2020

New research indicates that analyses of kidney biopsies from deceased donors don’t provide meaningful information beyond standard assessments of donor and recipient characteristics. In addition, the study revealed that relying on these analyses has prompted the discard of many potentially suitable organs for transplantation in the United States. The findings appear in JASN.

Despite a critical scarcity of organs available for transplantation, thousands of deceased donor kidneys are discarded each year in the United States.

Identification and characterization of trajectories of cardiac allograft vasculopathy after heart transplantation

5/4/2020

Every year, tens of thousands of deaths are due to end-stage heart failure in Europe and in the US combined. Heart transplantation is the ultimate treatment, but its number is dramatically limited due to the shortage of organs in those countries.

In the same time, the chances of survival beyond one year after transplantation have remained unchanged in recent years, despite significant progress in immunosuppressive therapy and patient care.

One of the most common reasons for long-term graft failure and patient death is an accelerated form of coronary artery disease called cardiac allograft vasculopathy. It is a frequent complication that affects up to half of patients within 10 years following heart transplantation. Yet, until now, little has been known about the different evolutive profiles of cardiac allograft vasculopathy and their risk factors.

Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study

3/3/2020

The first universal algorithm for predicting the risk of kidney transplant loss, named iBox, has been developed, validated and just made public by teams from Europe and the US.

The iBox is designed for clinicians to personalize and improve patient follow-up. The iBox could also accelerate the development of new immunosuppressive treatments by reducing the duration of clinical trials and defining a valid surrogate endpoint.

Chronic kidney disease affects 1 out of 10 people worldwide and is steadily increasing. When it reaches end-stage renal disease and endangers the lives of patients, dialysis or transplantation is required.

2019 AIMed Abstract Competition Winner Series: Marc Raynaud

1/23/2020

AIMed encouraged anyone who has innovative ideas of how artificial intelligence (AI) will transform the future of medicine and healthcare, to participate in our annual Abstract Competition.

For 2019, the winner is Marc Raynaud in the category "Decision Support and Hospital Monitoring" with his abstract "Multidimensional system to dynamically predict graft survival after kidney transplantation"

Paris Transplant Group at the SFT congress 2019

12/2/2019

The members of the Paris Transplant Group are present at the SFT congress which will take place from December 3, 2019 in Bordeaux, France.

Many lectures by the Paris Transplant Group are planned to present the ongoing research to the French transplant community. The presentations will cover:

The latest results of clinical research, including the TRANSFORM study carried out with Novartis,
Research on transplant prognosis for improved patient follow-up, including the iBox algorithm.
Advances made in understanding the mechanisms at work in the event of rejection or unsuccessful transplantation.

This research covers kidney, lung and other transplantation.

PTG awarded the ESOT StrongeR Together Pro Award

9/16/2019

The team of the Paris Transplant Group has been awarded at the ESOT 2019 congress in Copenhagen for its many contribution in the field of transplantation.

The Prize is given to a single Institution having submitted at least 5 abstracts for the event and granted with the best score. The Paris Transplant Group is very pleased to won this European award twice in a row.

Check out the contribution submitted by the Group on the ESOT website: esotcongress.org.

Disparities in Acceptance of Deceased Donor Kidneys Between the United States and France and Estimated Effects of Increased US Acceptance

8/26/2019

New publication in JAMA Internal Medicine: The first international analysis of renal transplant patient data shows that a change in allocation criteria in the United States could benefit patients on the waiting list. Thousands more kidneys could be transplanted each year if the United States used, as France does, kidneys from older donors.
Nearly 5,000 people in the United States and 3,500 in Europe die each year waiting for a kidney transplant. Yet, over the same period, in the United States, more than 3,500 available kidneys were discarded. The Journal of the American Medical Association (JAMA) Internal Medicine today published our results, obtained with the help of an international team, that compared the use of kidneys available in the United States and France between 2004 and 2014.

Using a new approach based on validated analytical methods and computer simulations, this work revealed that French transplant centres are much more likely to transplant kidneys from older donors than their American counterparts, and that this effectively increases the number of patients transplanted.

PTG at the 2019 ATC in Boston

5/14/2019

The American Transplant Congress, or ATC, is the not-to-be-missed event to exchange new scientific and clinical information from the field of transplantation.

Each year, transplant physicians, scientists, nurses, organ procurement personnel, pharmacists, allied health professionals, and other transplant professionals gather in this congress organized by the American Society of Transplant Surgeons and the American Society of Transplantation.

Dynamic prediction of renal survival among deeply phenotyped kidney transplant recipients using artificial intelligence: an observational, international, multicohort study

M. Raynaud wins the Leonardo Da Vinci Award at ESOT 2021

PTG at ESOT 2021

Marc Raynaud's Ph.D. DEFENSE

COVID-19-related medical research: a meta-research and critical appraisal

Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the US

Identification and characterization of trajectories of cardiac allograft vasculopathy after heart transplantation

Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study

2019 AIMed Abstract Competition Winner Series: Marc Raynaud

Paris Transplant Group at the SFT congress 2019

PTG awarded the ESOT StrongeR Together Pro Award

Disparities in Acceptance of Deceased Donor Kidneys Between the United States and France and Estimated Effects of Increased US Acceptance

PTG at the 2019 ATC in Boston

Paris Transplant Group

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