Category: Peter Reese

Dynamic prediction of renal survival among deeply phenotyped kidney transplant recipients using artificial intelligence: an observational, international, multicohort study

10/27/2021

For individuals with end-stage renal disease, kidney transplantation is the best treatment, in terms of quality and quantity of life and costs for society. Considering the organ shortage worldwide, the allograft failure is a real burden in chronic kidney disease, contributing to the growing number of the seven million individuals with end-stage renal disease. For these reasons, health agencies such as the Food and Drug Administation and the European Medicines Agency, have emphasized the need for developing a prediction model that would accurately predict the risk of allograft failure, which would allow clinicians to continuously enhance their prognostic judgements, and adapt the patient monitoring and management.

COVID-19-related medical research: a meta-research and critical appraisal

1/12/2021

As with many fields, science has been put to the test by the coronavirus pandemic. An international team of researchers, led by French scientists, has demonstrated novel scientific practices around Covid-19. Under the pressure of the number of cases and the urgent need to understand the virus, many research groups have shared results, sometimes to the expense of high scientific standards.

During the first wave of the Covid-19 epidemic, medical research saw a historic number of studies on the coronavirus published in a short period of time. An international consortium of experts in medical methodology undertook the major challenge of evaluating the Covid-19 research during this first wave.

Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the US

12/15/2020

New research indicates that analyses of kidney biopsies from deceased donors don’t provide meaningful information beyond standard assessments of donor and recipient characteristics. In addition, the study revealed that relying on these analyses has prompted the discard of many potentially suitable organs for transplantation in the United States. The findings appear in JASN.

Despite a critical scarcity of organs available for transplantation, thousands of deceased donor kidneys are discarded each year in the United States.

PTG at the ATC’s 2020 Virtual Congress

5/29/2020

Every year, the American Transplant Congress (ATC) gathers experts of organ transplantation from all over the world. For the 2020 edition, due to sanitary concerns and travel regulations, the in-person ATC initially planned in Philadelphia has been cancelled and replaced by a Virtual Congress. The event starts on 30 May 2020 for 3 days of live broadcasts.

The topic of ATC 2020 is “The Science of Tomorrow Starts Today” and covers the latest research in the field of transplantation. It showcases the research done in the industry too.

A considerable decline in the number of organ transplants since the start of the COVID-19 pandemic in France and the US

5/12/2020

A French-American study conducted by researchers from the Paris Transplant Group (University of Paris, Inserm and AP-HP) just published in The Lancet reveals a more than 90% drop in the number of organ procurement and transplants during the COVID-19 pandemic in France. The trend, which is also continuing across the Atlantic, poses a life-threatening risk to the thousands of people waiting for transplants in France and the United States.

Disparities in Acceptance of Deceased Donor Kidneys Between the United States and France and Estimated Effects of Increased US Acceptance

8/26/2019

New publication in JAMA Internal Medicine: The first international analysis of renal transplant patient data shows that a change in allocation criteria in the United States could benefit patients on the waiting list. Thousands more kidneys could be transplanted each year if the United States used, as France does, kidneys from older donors.
Nearly 5,000 people in the United States and 3,500 in Europe die each year waiting for a kidney transplant. Yet, over the same period, in the United States, more than 3,500 available kidneys were discarded. The Journal of the American Medical Association (JAMA) Internal Medicine today published our results, obtained with the help of an international team, that compared the use of kidneys available in the United States and France between 2004 and 2014.

Using a new approach based on validated analytical methods and computer simulations, this work revealed that French transplant centres are much more likely to transplant kidneys from older donors than their American counterparts, and that this effectively increases the number of patients transplanted.

Dynamic prediction of renal survival among deeply phenotyped kidney transplant recipients using artificial intelligence: an observational, international, multicohort study

COVID-19-related medical research: a meta-research and critical appraisal

Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the US

PTG at the ATC’s 2020 Virtual Congress

A considerable decline in the number of organ transplants since the start of the COVID-19 pandemic in France and the US

Disparities in Acceptance of Deceased Donor Kidneys Between the United States and France and Estimated Effects of Increased US Acceptance

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