PTG
  • Home
  • Research
    • PTG Research
    • iBox technology
    • Publications
    • Collaborations
    • Granted Projects
    • Awards
    • Database access
  • Platforms
    • Technical & Analytical Platforms
  • Team
    • Current team
    • PTG alumni
  • News & Media
    • Latest news
    • Photo and Video Gallery
    • PTG in the media
  • Job offers
  • About

Timing of anti-donor antibody responses affects the survival of kidney transplants

3/2/2017

 
Picture
Kidney rejection initiated by antibodies that were present before transplantation is linked with a better outcome that rejection due to antibodies that arise after transplantation
New research provides insights on transplant recipients’ antibody responses against donor kidneys and how the timing of those responses can have important implications. The findings appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN).
Picture
An antibody response against donor organs is the main cause of kidney rejection following transplantation. Antibodies can occur in 2 scenarios: before transplantation (preexisting donor-specific antibodies) and after transplantation (de novo donor-specific antibodies). Little is known about how these processes compare.

​Understanding the role of antibodies in transplant rejection is needed to guide matching of donors and recipients and to better prevent rejection. A team led by Alexandre Loupy, MD, PhD, Olivier Aubert, MD (INSERM U 970, Paris Translational Research Center for Organ Transplantation, in France), and Phil Halloran, MD, PhD (Alberta Transplant Applied Genomics Centre, in Canada) studied 205 patients who experienced antibodymediated rejection following kidney transplantation: 103 patients had pre-existing donorspecific antibodies and 102 patients had de novo donor-specific antibodies. There were various differences between patients with pre-existing vs. de novo donorspecific antibodies, but the most striking was the superior kidney survival experienced by the pre-existing group compared with the de novo group (63% vs. 34% at 8 years after rejection, respectively), regardless of treatment.
“Our study highlights that rejection due to antibodies that were present before transplantation is linked with a significantly better outcome that rejection due to de novo donor-specific antibodies,” said Dr. Aubert. ​
​The American Society of Nephrology®, ASN®, Kidney Week®, CJASN®, JASN®, NephSAP®, and ASN Kidney News® are registered trademarks of ASN “Our results encourage the transplantation of patients who have antibodies before transplant.

These patients would not normally have been considered as good candidates for transplantation and would have stayed on dialysis because of a high level of sensitization that prevents from finding a compatible kidney,” said Dr. Loupy. The findings also indicate the need to closely monitor patients for the development of de novo donorspecific antibodies so that therapies can be initiated to preserve kidney function.
The article, entitled “Antibody-Mediated Rejection Due to Preexisting versus De Novo Donor-Specific Antibodies in Kidney Allograft Recipients,” was published on March 2, 2017, doi: 10.1681/ASN.2016070797. ​

Comments are closed.

    Paris Transplant Group

    Our global aim is to accelerate the translation of immunological and gene expression discoveries into the clinical field by filling the gap between basic science and applied biomedical researches.

    CATEGORIES

    Awards
    Events
    Job offers
    Press Releases
    Publications

    See also

    Press coverage
    Video and ​Picture gallery

    ALl

    All
    Alexandre Loupy
    Antoine Bouquegneau
    Antoine Durrbach
    Antoine Roux
    Awards
    Blaise Robin
    Carmen Lefaucheur
    Charlotte Debiais
    Charlotte Loheac
    Christophe Legendre
    Daniel Yoo
    Dany Anglicheau
    Denis Glotz
    Denis Viglietti
    Dina Zielinski
    Elodie Bailly
    Events
    Gillian Divard
    Guillaume Bonnet
    Guillaume Coutance
    Huanxi Zhang
    Jean Luc Taupin
    Jean Paul Duong Van Huyen
    Jean Philippe Empana
    Jessy Dagobert
    Job
    Juliette Gueguen
    Kevin Louis
    Marc Raynaud
    Marie-Cécile Bories
    Marion Rabant
    Maud Racape
    Michel Delahousse
    Olivier Aubert
    Pascal Leprince
    Patrick Bruneval
    Peter Reese
    Press Releases
    Publications
    Shaida Varnous
    Valentin Goutaudier
    Xavier Jouven
    Yassine Bouatou
    Zeynep Demir

    Archives

    October 2021
    September 2021
    August 2021
    July 2021
    February 2021
    January 2021
    December 2020
    November 2020
    October 2020
    September 2020
    August 2020
    July 2020
    May 2020
    March 2020
    January 2020
    December 2019
    October 2019
    September 2019
    August 2019
    June 2019
    May 2019
    March 2019
    February 2019
    December 2018
    September 2018
    May 2018
    February 2018
    January 2018
    December 2017
    November 2017
    October 2017
    September 2017
    June 2017
    May 2017
    April 2017
    March 2017
    February 2017
    January 2017
    December 2016
    November 2016
    June 2016
    April 2016
    October 2015
    June 2015
    August 2014
    January 2014
    September 2013
    January 2013
    June 2011
    August 2010
    May 2009

    RSS Feed

Paris Transplant Group

About PTG
PTG Team
​​Careers at PTG
​Latest News
​
Awards
Video and Picture Gallery

PTG in the Press
​Contact us

Research

iBox technology
PTG Research
PTG Publications
Covid-related research 🔓

Platforms

Technical platforms

Partnerships

Research collaborations
​Database access
​

Search

LEGAL NOTICE AND PRIVACY POLICY
© COPYRIGHT 2022. ALL RIGHTS RESERVED.

 LABS EXPLORER for the PARIS TRANSPLANT GROUP.
  • Home
  • Research
    • PTG Research
    • iBox technology
    • Publications
    • Collaborations
    • Granted Projects
    • Awards
    • Database access
  • Platforms
    • Technical & Analytical Platforms
  • Team
    • Current team
    • PTG alumni
  • News & Media
    • Latest news
    • Photo and Video Gallery
    • PTG in the media
  • Job offers
  • About